Lipinski Rule of 5

Length of extracted atom information:

Protein(ATOM) Molecular Weight:

Ligand(HETATM) Molecular Weight:

Hydrogen Bond Acceptors:

Hydrogen Bond Donors:

Log P:

Lipinski's Rule of Five Violations: 


  

  

      

        
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Lipinski rule of 5 helps in distinguishing between drug like and non drug like molecules.
        It predicts high probability of success or failure due to drug likeness for molecules complying with 2 or more of the following rules

    

    

        
    
          
  • Molecular mass less than 500 Dalton
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  • High lipophilicity (expressed as LogP less than 5)
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  • Less than 5 hydrogen bond donors
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  • Less than 10 hydrogen bond acceptors
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  • Molar refractivity should be between 40-130
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